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- No adequate human data in 1st trimester exposure but reported doubtful association with some congenital anomalies (anencephaly, cerebral palsy, microphthalmia, nasal cleft, and tooth staining) and fetal death.
- Use of the drug in 3rd trimester causes constriction of ductus arteriosus with subsequent pulmonary hypertension and oligohydramnios by affecting fetal renal function.
- Inhibits labor, prolongs pregnancy.
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