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Generic
Name |
Clonazepam |
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Trade Name |
Apo-clonazepam |
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Manufacturer |
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Risk
Category |
|
| D |
- Positive evidence of human fetal risk exists.
- Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
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Indication |
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|
 |
- Benzodiazepine.
- Anticonvulsant, antipanic.
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Fetal Risk
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|
 |
- Cause cleft palate, open eyelids, limb defects if used during organogenesis in animals.
- Crosses human placenta.
- No adequate human data but other benzodiazepines increase the risk of congenital anomalies if used in 1st trimester.
- Chronic use in pregnancy causes neonatal withdrawal.
- If used in last weeks of pregnancy it causes neonatal central nervous system depression, respiratory problems, poor feeding, hypothermia and neonatal flaccidity.
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Breast Feeding
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 |
- Assumed to be excreted into milk because of similarity to other benzodiazepines.
- Benzodiazepines can cause sedation, weight loss and poor feeding in nursing infants.
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